Author(s)

Kishor S. Jain, Swapnil. K. Chaudhari, Nikhil S. More, Kapil D. More, Sachin A Wakedkar, M. K. Kathiravan

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Microwave Assisted Organic Synthesis (MAOS) is energy efficient and effective tool to speed up the synthesis for drug discovery process. In the present study we report a novel protocol for the rapid, high throughput synthesis of mononuclear 2-amino-5-cyano-4,6-disubstituted pyrimidines, adaptable to parallel synthesis for compound libraries. The overall reaction time in hrs has been reduced to 25 - 50 minutes with improved yields.

Microwave Assisted Organic Synthesis (MAOS), 2-Amino-5-Cyano-2, 6-Disubstitutedpyrimidines, Α-Cyanoketene S, S-Acetals

Jain, K. , Chaudhari, S. , More, N. , More, K. , Wakedkar, S. and Kathiravan, M. (2011) A Facile Synthesis of 2-Amino-5-Cyano-4, 6-Disubstitutedpyrimidines under MWI. International Journal of Organic Chemistry, 1, 47-52. doi: 10.4236/ijoc.2011.12009.