Author(s)

Zinia Jaman¹, Mohammad R. Karim^1*, Korsi Dumenyo², Aminul H. Mirza³

¹Department of Chemistry, Tennessee State University, Nashville, USA.
²Department of Agriculture, Tennessee State University, Nashville, USA.
³Faculty of Science, Universiti Brunei Darussalam, Bandar Seri Begawan, Brunei.

Schiff bases are known to possess anticancer, antibacterial, antifungal, antitubercular, anti-inflammatory, antimicrobial and antimalarial properties. In this paper antibacterial studies against variety of plants and human pathogenic bacteria with eight newly synthesized Schiff bases and several intermediate silyl compounds have been reported. The antibacterial activities of the synthesized compounds were primarily determined by paper disc diffusion method. The minimum inhibitory concentration (MIC) of each compound was also determined by tube dilution process. Seven different human pathogenic bacteria and eighteen different plant pathogenic bacteria were used for the antibacterial activity studies. While all synthesized compounds have shown significant antibacterial activity, one intermediate silyl compound has shown remarkably high antibacterial property. 5-substituted derivatives have shown relatively higher activity than non-substituted compounds. Polar substituent which increases hydrophilicity may have a positive impact on the antibacterial property.

5-Nitro-1, 10-phenanthroline Dialdehyde, 5-Bromo-1, 10-phenanthroline Dialdehyde, Schiff Bases, S-Alkyl/Aryldithiocarbazates, Thiosemicarbazide

Jaman, Z. , Karim, M. , Dumenyo, K. and Mirza, A. (2014) Antibacterial Activities of New Schiff Bases and Intermediate Silyl Compounds Synthesized from 5-Substituted-1,10-phenanthroline- 2,9-dialdehyde. Advances in Microbiology, 4, 1140-1153. doi: 10.4236/aim.2014.415124.