ABSTRACT
Environment
chemical pollution can be persistent, and even virtually irremovable. For some
chemicals in the workplace environment reliably safe low exposure levels are
technically unattainable or presumably nonexistent. As a supplement to
decreasing harmful exposures to as low levels as possible, the “biological
prophylaxis” aims at enhancing host’s protective mechanisms. During over 30
years in animal experiments modeling isolated or combined chronic or subchronic
exposures to silica, asbestos, monazite, lead, chromium, arsenic, manganese,
nickel, vanadium, nanosilver, nanocopper, formaldehyde, phenol, naphthalene,
benzo(a)pyrene we tested so-called “bioprophylatic complexes” (BPCs) comprising
innocuous substances with theoretically expected beneficial influence on the
toxicokinetics and/or toxicodynamics of those toxics. The BPCs proved
protectively effective in animal experiments were then subjected to controlled
field trials on restricted groups of volunteers. Once the effectiveness and
safety of a BPC was established, it was recommended for practical use, first of
all, in the most vulnerable population groups (children, pregnant women) and in
the most harmful occupations. At each stage of this work the effectiveness of
the bioprophylactic approach to chemical risks management was successfully
demonstrated. The BPCs tested up to now proved capable of mitigating systemic
toxicity, cytotoxicity, fibrogenicity, and mutagenicity of the above-listed
chemicals.
Share and Cite:
Katsnelson, B. , Privalova, L. , Gurvich, V. , Kuzmin, S. , Kireyeva, E. , Minigalieva, I. , Sutunkova, M. , Loginova, N. , Malykh, O. , Yarushin, S. , Soloboyeva, J. and Kochneva, N. (2014) Enhancing Population’s Resistance to Toxic Exposures as an Auxilliary Tool of Decreasing Environmental and Occupational Health Risks (a Self-Overview).
Journal of Environmental Protection,
5, 1435-1449. doi:
10.4236/jep.2014.514137.