A solid superacid catalyst Pt-SO₄^2-/ZrO₂-A1₂O₃ for n-pentane isomerization, was prepared by incipient-wetness impregnation. Preparetion conditions, namely, calcination temperature, concentration of sulfuric acid solution used in impregnation and Al₂O₃ concentration, were varied to investigate the effects on catalytic performance of Pt-SO₄^2-/ZrO₂-A1₂O₃. The results showed that the PtSZA catalyst exhibited excellent catalytic performance for n-pentane isomerization. Under optimized preparation conditions of calcination temperature of 650°C, reaction time for 3 h, concentration of sulfuric acid solution for 0.5 mol/L, 30% of Al₂O₃ concentration and 0.3% of Pt concentration, the n-pentane conversion and isopentane selectivity of Pt-SO₄^2-/ZrO₂-A1₂O₃ could reach up to 62.17% and 91.60%, respectively.