Objectives: Agricultural related injury has not been explored in Guinea. We aimed to describe the causes of agricultural related injury so as to improve safety practice on farms in Guinea. Methods: A retrospective descriptive analysis was made to present the nonfatal agricultural injuries in Guinea in 2012. Results: In 2012, 40,587 people (36.5/10,000 population) endured the agricultural injuries events in Guinea. The most important agents of injury in descending order included overexertion (30.2%), cutting (22.9%), motor vehicle accidents (9.9%), venomous animal (9.4%) and injury from animal (9.0%). The entire male age groups exhibit the same major cause patterns of farming injury as female for overexertion and strenuous movements, cutting or piercing instrument or object and injury from animal. The reality is that female populations tend to sustained higher agricultural-related to motor vehicle accidents, but less venomous animal and agricultural machinery injuries than male populations. Also, female appeared to sustain hot, caustic, or corrosive object related injury than male except for male aged 65 years and over. Male as well as female aged over 65 years was highly exposed to fall than their younger counterparts. Males slightly bore higher morbidity than females (42.5 vs. 30.8/10,000 population). Conclusions: Cutting or piercing instrument, motor vehicle accidents, venomous animal, and injury from animal which were held accountable for the majority of total injury morbidity risk factors in Guinea. The importance of agricultural risk factors differs by sex and age. Consequently, it is suggested that preventive intervention strategies should be accordingly tailored to reduce farm work-related injuries.