Geometrical study on diseaserelated ncRNAs based on Z-curve method ()
ABSTRACT
The Z curve is a very useful method for visual-izing and analyzing DNA sequences. It is a three-dimensional space curve that constitutes a unique representation of a given DNA se-quence. It becomes more and more important to study non-coding regions in the recent years. Using Z curve method, 15 disease-related ncRNAs and some snoRNAs and miRNAs sequences are selected from the NONCODE database in this paper, which relate to Alzheimer Disease. The corresponding Z curves of the studied ncRNAs, sequences have been mapped and compared. The statistical features of the Z curves are ob-tained. These features indicate that the ncRNAs sequences playing same roles in the celluar process have almost the same Z-curves. And the base content in these sequences is almost same too.
Share and Cite:
Yang, Y. and Wang, J. (2009) Geometrical study on diseaserelated ncRNAs based on Z-curve method.
Health,
1, 24-30. doi:
10.4236/health.2009.11005.
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