Author(s)

Krishnaswamy Velmurugan, Lijun Tang, Raju Nandhakumar

College of Chemistry and Chemical Engineering, Liaoning Key Laboratory for the Synthesis and Application of Functional Compounds, Bohai University, Jinzhou, China.
Synthesis and Chemosensor Lab, Department of Chemistry, Karunya University, Coimbatore, India.

Four binol based pyrrole carboxamide chiral receptors has been synthesized and effectively used as a Chirality Conversion Reagent (CCR) for underivatized amino acids. Three points of interactions take place for the conversion process. They are the reversible imine formation, the internal resonance assisted Hydrogen Bonding (RAHB) and the additional hydrogen bonds between the amino acids and the heterocylic moiety of the pendant groups. The conversion efficiency of all the receptors was found to be comparable with those of the receptors reported earlier.

Binol Based Receptors; Chiral Recognition; Amino Acids; Amino Alcohols; Chiral Inversion; 1H-NMR

Velmurugan, K. , Tang, L. and Nandhakumar, R. (2014) Binol Based Chirality Conversion Reagents for Underivatized Amino Acids. International Journal of Organic Chemistry, 4, 40-47. doi: 10.4236/ijoc.2014.41006.