Author(s)

Tomoko Mineno, Mamika Shinada, Kazuki Watanabe, Hitoshi Yoshimitsu, Hiroyuki Miyashita, Hisao Kansui

Laboratory of Medicinal Chemistry, Faculty of Pharmacy, Takasaki University of Health and Welfare, Takasaki, Japan.
Laboratory of Natural Medicines, Faculty of Pharmaceutical Sciences, Sojo University, Kumamoto, Japan.
Laboratory of Organic Chemistry for Life Sciences, Faculty of Pharmacy, Takasaki University of Health and Welfare, Takasaki, Japan.
Laboratory of Organic Chemistry, Faculty of Pharmaceutical Sciences, Sojo University, Kumamoto, Japan.

Indium(III) triflate, a trivalent indium reagent, was shown to be a highly-efficient catalyst for the conversion of primary amides to the corresponding nitriles. The successful reactions required 5 mol% of indium(III) triflate, and toluene was proved to be the most suitable solvent. Various amides were subjected to this method, and each produced the corresponding nitriles in excellent yields.

Indium(III) Triflate; Primary Amides; Nitriles

Mineno, T. , Shinada, M. , Watanabe, K. , Yoshimitsu, H. , Miyashita, H. and Kansui, H. (2014) Highly-Efficient Conversion of Primary Amides to Nitriles Using Indium(III) Triflate as the Catalyst. International Journal of Organic Chemistry, 4, 1-6. doi: 10.4236/ijoc.2014.41001.