Author(s)

Emil Kuriakose, Elena Lascu, Y. Lynn Wang, Stefani Gjoni, Nicholas C. P. Cross, Ruth Baumann, Kerilee Tam, Ellen Scherl, Randy S. Longman, Richard T. Silver

Department of Pathology, University of Chicago, Chicago, USA.
Division of Hematology and Medical Oncology, Weill Cornell Medical College, New York, USA.
Jill Roberts Center for Inflammatory Bowel Disease, Division of Gastroenterology, Weill Cornell Medical College, New York, USA.
Wessex Regional Genetics Laboratory, Salisbury District Hospital, University of Southampton, Salisbury, UK.

Patients with IBD frequently have hematologic abnormalities suggestive of JAK2 mutated MPNs, but are traditionally classified as reactive processes. Haplotype 46/1 is a well-characterized genetic predisposition, common to both inflammatory bowel disease (IBD) and myeloproliferative neoplasms (MPN). In view of this shared genetic predisposition, we measured the frequency of the JAK2^V617F mutation in IBD patients with thrombocytosis or erythrocytosis, in order to ascertain whether a higher than expected proportion of these patients may in fact have underlying MPNs. 1121 patients were identified with an active diagnosis of Crohn’s disease or ulcerative colitis, of which 474 had either thrombocytosis or erythrocytosis. Patients with abnormal counts were tested for the JAK2^V617F mutation during routine follow-up visits. Interim analysis of first 23 patients tested was performed to assess whether the JAK2^V617F positivity rate was statistically significant compared with known expected frequencies in a comparable control population. Of 23 patients, 13 patients had thrombocytosis and 10 had erythrocytosis. Three patients with thrombocytosis (23%), and 1 patient with erythrocytosis (10%), tested positive for JAK2^V617F, exceeding the expected thresholds for statistical significance. In patients with IBD and thrombocytosis or erythrocytosis, a meaningful proportion may harbor an undiagnosed MPN, as indicated by clonal abnormalities such as JAK2^V617F. These findings imply the need for increased testing of these patients for clonal hematologic abnormalities, and importantly, if found, suggest the need for therapeutic strategies with drugs, such as JAK2 inhibitors, in patients with both MPN and IBD.

JAK2^V617F; Myeloproliferative Neoplasms; Inflammatory Bowel Disease; Thrombocythemia; Polycythemia

E. Kuriakose, E. Lascu, Y. Wang, S. Gjoni, N. Cross, R. Baumann, K. Tam, E. Scherl, R. Longman and R. Silver, "The JAK2^V617F Mutation Seen in Myeloproliferative Neoplasms (MPNs) Occurs in Patients with Inflammatory Bowel Disease: Implications of a Pilot Study," International Journal of Clinical Medicine, Vol. 4 No. 12A, 2013, pp. 10-15. doi: 10.4236/ijcm.2013.412A1003.