Open Journal of Genetics
Volume 3, Issue 4 (December 2013)
ISSN Print: 2162-4453 ISSN Online: 2162-4461
Google-based Impact Factor: 0.21 Citations
ATF3 rSNPs, transcriptional factor binding sites and human etiology ()
Affiliation(s)
ABSTRACT
Three rSNPs (rs3125289, rs1877474 and rs11119982) in one intron of the activating transcription factor 3 (ATF3) gene have been significantly associated with the human etiology of hypospadias and may be associated with human disease. These rSNP alleles alter the DNA landscape for potential transcriptional factors (TFs) to attach resulting in changes in transcriptional factor binding sites (TFBS). These TFBS changes are examined with respect to the human etiology of hypospadias which has been found to be significantly associated with the rSNPs.
KEYWORDS
Share and Cite:
Cited by
Copyright © 2024 by authors and Scientific Research Publishing Inc.
This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.