Integrating various data sets to provide one optimal subsurface image is a major goal of geophysicst. In this paper, there is a synergetic approach used to delineate the tectonic-structural framework with analyzing the hydrocarbon reservoir in the Lower Indus Platform basin of Pakistan. The reflected seismic profiles and potential field map constitute the data base of this study. Our study in the line of the previous research is resulted from important oil and gas discoveries contained in the Early Cretaceous and Upper Jurassic formations of the Lower Indus Platform basin area. The result shows trapping mechanism in the Lower Indus Platform basin involves of the fault blocks and stratigraphic traps are present in the area. The more refined images are interpreted to provide greater insight into detailed integrated geophysical study of area.