Author(s)

Rocío López, Diana Castro-Villabón, Johanna Álvarez, Alonso Vera, Rafael Andrade

Pathology Department, Hospital Universitario Fundación Santa Fe de Bogotá, Bogotá D.C., Colombia.
Pathology Department, Hospital Universitario Fundación Santa Fe de Bogotá, Bogotá D.C., Colombia Faculty of Medicine, Universidad de Los Andes, Bogotá D.C., Colombia.
Surgery Department, Hospital Universitario Fundación Santa Fe de Bogotá, Bogotá D.C., Colombia.

Background: Hepatic angiosarcoma is a rare tumor of endothelial origin that accounts for up to 2% of all primary neoplasms of the liver. It is uncommon in young adults and acute liver failure is a very unusual presentation of this disease. Case Presentation: We report the cases of two young male adults who presented with acute liver failure. One of them was diagnosed with primary hepatic angiosarcoma after transplantation based on the complete evaluation of the heaptectomy specimen; while the other was diagnosed through a liver biopsy which was done as part of the work-up for transplantation. Both patients had a rapidly worsening clinical course and died within 2 months of diagnosis. Conclusion: Hepatic angiosarcoma is a poor prognosis disease with high and early mortality. Therefore, a high level of suspicion should be present to promptly diagnose it, especially when dealing with patients with a rapidly worsening liver disease.

Liver; Hepatic Angiosarcoma; Acute Liver Failure

López, R. , Castro-Villabón, D. , Álvarez, J. , Vera, A. and Andrade, R. (2013) Hepatic angiosarcoma presenting as acute liver failure in young adults. Report of two cases and review of literature. Case Reports in Clinical Medicine, 2, 439-444. doi: 10.4236/crcm.2013.28115.