The synergistic effects of green tea polyphenols and antibiotics against potential pathogens - Advances in Bioscience and Biotechnology

ABB > Vol.4 No.11, November 2013

Advances in Bioscience and Biotechnology

Volume 4, Issue 11 (November 2013)

ISSN Print: 2156-8456 ISSN Online: 2156-8502

Google-based Impact Factor: 1.18 Citations h5-index & Ranking

The synergistic effects of green tea polyphenols and antibiotics against potential pathogens ()

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Download as PDF (Size: 330KB) PP. 959-967

DOI: 10.4236/abb.2013.411127 5,999 Downloads 10,889 Views Citations

Author(s)

Bobak Haghjoo, Lee H. Lee, Umme Habiba, Hassan Tahir, Moe Olabi, Tin-Chun Chu

Affiliation(s)

Department of Biological Sciences, Seton Hall University, South Orange, USA.
Department of Biology & Molecular Biology, Montclair State University, Montclair, USA.

ABSTRACT

Green tea leaves contain many polyphenolic compounds such as (-)-epicatechin (EC), (-)-epicatechin-3-gallate (ECG), (-)-epigallocatechin (EGC), and (-)epigallocatechin-3-gallate (EGCG). These polyphenol compounds have been implicated to have distinct properties that combat the harmful effects of cell proliferation. They contain certain anti-viral and antibacterial properties that inhibit growth. In this study, 1% green tea and modified lipophilic green tea polyphenols (GTP and LTP) were used in combination with the most commonly prescribed antibiotics to study their effects on gram-positive, gram-negative, and acid-fast bacteria. The results indicated that 1% GTP and 1% LTP provided different synergistic effects on several antibiotics in various bacteria. It was found that 1% GTP works the best synergistically against Enterobacter aerogenes, making the resistant strain susceptible to 8 out of 12 antibiotics used. 1% LTP worked the best on Escherichia coli and was able to convert 7 antibiotic resistant categories to susceptible. In addition, 1% LTP was also able to inhibit the growth of Serratia marcescens synergistically with 3 antibiotics. These results suggest that 1% GTP and 1% LTP provide beneficial effects on selected antibiotics against microbial growth and are able to reverse the antibiotic resistance to susceptible. Green tea polyphenols could serve as natural alternatives to combat against antibiotic resistance pathogens.

KEYWORDS

GTP; LTP; Green Tea Polyphenols; Pathogenic Microorganisms; Kirby-Bauer Disk Diffusion Method; Antibiotic Resistance

Share and Cite:

Haghjoo, B. , Lee, L. , Habiba, U. , Tahir, H. , Olabi, M. and Chu, T. (2013) The synergistic effects of green tea polyphenols and antibiotics against potential pathogens. Advances in Bioscience and Biotechnology, 4, 959-967. doi: 10.4236/abb.2013.411127.

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