Author(s)

Maduike C. O. Ezeibe, Okechukwu K. Ezeobele, Mfon E. Esen, Augustine A. Ngene, Ijeoma J. Mbuko, Ijeoma C. Chukwudi, Valentine U. Omoja, Ikenna O. Ezeh

Department of Veterinary Medicine, University of Nigeria Nsukka, Nigeria;.
Department of Veterinary Parasitology and Entomology, University of Nigeria, Nsukka, Nigeria.
Department of Veterinary Physiology and Pharmacology, University of Nigeria, Nsukka, Nigeria.

To treat resistant Escherichia coli infection in chicks, Ampicillin was stabilized with a synthetic aluminum-magnesium silicate (AMS) to prolong its bioavailability. Its dose was also reduced to minimize adverse side effects. Vitamins A, C, E and Selenium levels in the chicks’ feeds were increased to enhance immune response of the chicks. E. coli coloning forming units, per ml of bile of the chicks, treated with Ampicillin and with Ampicillin in AMS, were: 228800.00 ± 90103.50 and 134500.00 ± 44937.97 at 10 mg/kg, 104400.00 ± 36024.44 and 34800.00 ± 8014.97 at 7.5 mg/kg, 198400.00 ± 129301.80 and 156800.00 ± 109392.70 at 5 mg/kg. Mean bacterial loads of the untreated groups, fed normal feed and those fed the fortified feed were 824400.00 ± 322424.80 and 534800.00 ± 277832.80. At 7.5 mg/kg. Ampicillin in the AMS, effectively (P < 0.05) treated resistant E. coli infection in chicks, fed immune-stimulants, with the infection rate reduced by 95.8%.

Prolonging Bioavailability of Drugs; Minimizing Side Effects of Drugs; Enhancing Immune Responses of Patients

Ezeibe, M. , Ezeobele, O. , Esen, M. , Ngene, A. , Mbuko, I. , Chukwudi, I. , Omoja, V. and Ezeh, I. (2013) Synergy in antibacterial activities of Ampicillin trihydrate, stabilized with a synthetic aluminum-magnesium silicate and immune-stimulants, on resistant Escherichia coli infection. Health, 5, 1548-1552. doi: 10.4236/health.2013.510210.