Author(s)

Yasser K. Abdelmonem, Farag A. El-Essawy, Saeda A. Abou El-Enein, Mona M. El-Sheikh-Amer

Department of Chemistry, Faculty of Science, Menoufia University, Shebin El-Koam, Egypt.

Synthesis of some 1,3,4-thia-, oxa-diazol and 1,2,4 triazole incorporated the biologically active and the pyrazolopyri-dine derivative. Molecular modeling and docking of the active compounds into AKR1C3 complexed with its bound inhibitor indomethacin using Molsoft ICM 3.4-8C program were performed in order to predict the affinity and orientation of the synthesized compounds at the active site.

Pyrazolopyridine; Biologically Active; Molecular Modeling and Inhibitor

Abdelmonem, Y. , El-Essawy, F. , Abou El-Enein, S. and El-Sheikh-Amer, M. (2013) Docking Studies, Synthesis, and Evaluation of Antioxidant Activities of N-Alkylated, 1,2,4-Triazole, 1,3,4-Oxa-, and Thiadiazole Containing the Aminopyrazolopyridine Derivatives. International Journal of Organic Chemistry, 3, 198-205. doi: 10.4236/ijoc.2013.33026.