Author(s)

Ying-Cheng Huang¹, Wei-Ting Chen², Shu-Fan Tien², Ho-Lien Huang², Chun-Nan Yeh³, Kun-I Lin^4*, Chung-Shan Yu⁵

¹Department of Neurosurgery, Chang Gung Memorial Hospital at Linkou, Chang Gung University, Taoyuan City.
²Department of Biomedical Engineering and Environmental Sciences, National Tsing-Hua University, Hsinchu City.
³Department of Surgery, Chang Gung Memorial Hospital at Linkou, Chang Gung University, Taoyuan City.
⁴Department of Obsterics and Gynecology, Chang Bing Show Chwan Memorial Hospital, Changhua City.
⁵Institute of Nuclear Engineering and Science, National Tsing-Hua University, Hsinchu City.

Four a-galactosyl phytosphingosine 2,6’-diamide analogs were prepared from 2,6’-diamino a-galactosylphytosphingosine and the aromatic-bearing carboxylic acids. After purification with High Performance Liquid Chromatography, a flowcytometry for the four compounds for stimulation of human Va24+/Vb11+ NKT cell populations was carried out. Additional keto groups on the acyl chains of the 2,6’-diamide compound was associated with the enhanced stimulating effect.

Phytosphingosine; HPLC; Keto; Flow Cytometry; Simulation

Y. Huang, W. Chen, S. Tien, H. Huang, C. Yeh, K. Lin and C. Yu, "α-Galactosyl Phytosphingosine 2,6’-Diamide as an Inducer of Invariant Natural Killer T Cell," Open Journal of Medicinal Chemistry, Vol. 3 No. 3, 2013, pp. 55-59. doi: 10.4236/ojmc.2013.33008.