SNPs and TFBS Associated with High Altitude Sickness* - Open Journal of Blood Diseases

OJBD > Vol.3 No.3, September 2013

Open Journal of Blood Diseases

Volume 3, Issue 3 (September 2013)

ISSN Print: 2164-3180 ISSN Online: 2164-3199

Google-based Impact Factor: 0.56 Citations

SNPs and TFBS Associated with High Altitude Sickness* ()

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Download as PDF (Size: 194KB) PP. 85-93

DOI: 10.4236/ojbd.2013.33018 3,900 Downloads 6,309 Views Citations

Author(s)

Norman E. Buroker, Xuehan Ning, Zhaonian Zhou, Kui Li, Weijun Cen, Xiufeng Wu, Weizhong Zhu, C. Ronald Scott, Shihan Chen

Affiliation(s)

Center for Cardiovascular Biology and Regenerative Medicine, University of Washington, Seattle, USA..
Department of Pediatrics, University of Washington, Seattle, USA.
Department of Pediatrics, University of Washington, Seattle, USA;.
Division of Cardiology, Seattle Children’s Hospital, Institute, Foundation, Seattle, USA;.
Laboratory of Hypoxia Physiology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.
Laboratory of Hypoxia Physiology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China;.
People’s Hospital of the Tibet Autonomous Region, Lhasa, China;.

ABSTRACT

The rSNPs for the genes AKT3 (rs4590656), EGLN1 (rs480902), eNOS3 (rs1007311), and VEGFA (rs699947, rs13207311, rs1570360, rs2010963) have been significantly associated with the physiological parameters in high altitude sickness Han or Tibetan Chinese patients at the Qinghai-Tibetan plateau. The alleles of each rSNP have been found to create unique transcriptional factor binding sites for transcription factors that affect the process of hypoxia gene expression in this high altitude hypoxia environment.

KEYWORDS

High Altitude Sickness; rSNPs; TFBS

Share and Cite:

Buroker, N. , Ning, X. , Zhou, Z. , Li, K. , Cen, W. , Wu, X. , Zhu, W. , Ronald Scott, C. and Chen, S. (2013) SNPs and TFBS Associated with High Altitude Sickness*. Open Journal of Blood Diseases, 3, 85-93. doi: 10.4236/ojbd.2013.33018.

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