Author(s)

Daniel Moersdorf, Pierre Hugounenq, Lai Truonc Phuoc, Hind Mamlouk-Chaouachi, Delphine Felder-Flesch, Sylvie Begin-Colin, Geneviève Pourroy, Ingolf Bernhardt

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The interactions of two types of cells (red blood cells, Caco-2 cells) with magnetic iron oxide nanoparticles (non-grafted, citrate-grafted, dendrimer-grafted) of 11 nm in size have been investigated. We focused on two important physiological parameters of the cells, the intracellular pH and the intracellular Ca2+ content. The results show that the nanoparticles do not have a significant influence on the pH and Ca2+ content of Caco-2 cells. The Ca2+ content of red blood cells is also not affected but the intracellular pH is slightly reduced.

Red Blood Cells; Caco-2 Cells; Ca2+ Content; Intracellular PH; Magnetic Iron Oxide Nanoparticles

Moersdorf, D. , Hugounenq, P. , Phuoc, L. , Mamlouk-Chaouachi, H. , Felder-Flesch, D. , Begin-Colin, S. , Pourroy, G. and Bernhardt, I. (2010) Influence of magnetic iron oxide nanoparticles on red blood cells and Caco-2 cells. Advances in Bioscience and Biotechnology, 1, 439-443. doi: 10.4236/abb.2010.15057.