The talented interferon-gamma - Advances in Bioscience and Biotechnology

ABB > Vol.4 No.7, July 2013

Advances in Bioscience and Biotechnology

Volume 4, Issue 7 (July 2013)

ISSN Print: 2156-8456 ISSN Online: 2156-8502

Google-based Impact Factor: 1.18 Citations h5-index & Ranking

The talented interferon-gamma ()

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DOI: 10.4236/abb.2013.47A3002 7,122 Downloads 11,755 Views Citations

Author(s)

Fan-Ching Lin, Howard A. Young

Affiliation(s)

Laboratory of Experimental Immunology, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, Frederick, USA.

ABSTRACT

IFN-γ is an extraordinarily pleotropic cytokine. It can not only heighten both the innate and adaptive immune response against pathogens and tumors, but also has the ability to maintain immune homeostasis. Since the effects of IFN-γ are cell and tissue specific, it is important to consider the recent advances in IFN-γ signaling in the context of different diseases. To this end, we review the involvement of IFN-γ in the pathogenesis of several inflammatory diseases, its therapeutic potential as an anti-tumor agent and its effects upon stem cells.

KEYWORDS

IFN-γ; Inflammation; Autoimmune; Cancer; Inflammatory Bowel Diseases; Neurodegenerative Diseases; Stem Cells

Share and Cite:

Lin, F. and Young, H. (2013) The talented interferon-gamma. Advances in Bioscience and Biotechnology, 4, 6-13. doi: 10.4236/abb.2013.47A3002.

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