American Journal of Analytical Chemistry

Volume 4, Issue 6 (June 2013)

ISSN Print: 2156-8251   ISSN Online: 2156-8278

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Use of Cucurbit [6] Uril as a Modifier in the Electrochemical Determination of Antitumor Platinum (II) Complex: Trans-[PtCl2(Dimethylamine) (Isopropylamine)]. Application to Biological Samples

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DOI: 10.4236/ajac.2013.46040    3,457 Downloads   5,311 Views  Citations

ABSTRACT

A square wave voltammetry (DPV) method for trans-Pt[Cl2(Dimethylamine)(isopropylamine)] determination is developed. To this end, all the chemical and instrumental variables affecting the determination of trans-Pt[Cl2(Dimethylamine) (isopropylamine)] are optimized. From studies of the mechanisms governing the electrochemical response of trans-Pt[Cl2(Dimethylamine)(isopropylamine)], it was concluded that it was an electrochemically reversible system with an adsorptive oxidation phenomenon. Under optimal conditions, the variation of analytical signal (Ip) with trans-Pt[Cl2(Dimethylamine)(isopropylamine)] concentration was linear in the 0.05 μg·mL-1 to 10 μg·mL-1 range, with a LOD 91 μg·mL-1 of and a LOQ of 303 μg·mL-1, a RSD 1.10% and Er 0.72%. The optimized method was applied to the determination of trans-Pt[Cl2(Dimethylamine)(isopropylamine)] in biological fluids, in human urine and synthetic urine.

Share and Cite:

C. Domínguez and P. Hernández, "Use of Cucurbit [6] Uril as a Modifier in the Electrochemical Determination of Antitumor Platinum (II) Complex: Trans-[PtCl2(Dimethylamine) (Isopropylamine)]. Application to Biological Samples," American Journal of Analytical Chemistry, Vol. 4 No. 6, 2013, pp. 314-322. doi: 10.4236/ajac.2013.46040.

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