Author(s)

Carmen S. H. Domínguez, Pedro Hernández

Departamento de Química Analítica y Análisis Instrumental, Facultad de Ciencias, Universidad Autónoma de Madrid, Cantoblanco, Madrid, Spain.

A square wave voltammetry (DPV) method for trans-Pt[Cl₂(Dimethylamine)(isopropylamine)] determination is developed. To this end, all the chemical and instrumental variables affecting the determination of trans-Pt[Cl₂(Dimethylamine) (isopropylamine)] are optimized. From studies of the mechanisms governing the electrochemical response of trans-Pt[Cl₂(Dimethylamine)(isopropylamine)], it was concluded that it was an electrochemically reversible system with an adsorptive oxidation phenomenon. Under optimal conditions, the variation of analytical signal (Ip) with trans-Pt[Cl₂(Dimethylamine)(isopropylamine)] concentration was linear in the 0.05 μg·mL^-1 to 10 μg·mL^-1 range, with a LOD 91 μg·mL^-1 of and a LOQ of 303 μg·mL^-1, a RSD 1.10% and Er 0.72%. The optimized method was applied to the determination of trans-Pt[Cl₂(Dimethylamine)(isopropylamine)] in biological fluids, in human urine and synthetic urine.

Trans-[PtCl₂(Dimethylamine)(Isopropylamine)]; Differential Pulse Voltammetry (DPV); Square Wave Voltammetry (SWV); Biological Fluids; Human Urine

Domínguez, C. and Hernández, P. (2013) Use of Cucurbit [6] Uril as a Modifier in the Electrochemical Determination of Antitumor Platinum (II) Complex: Trans-[PtCl₂(Dimethylamine) (Isopropylamine)]. Application to Biological Samples. American Journal of Analytical Chemistry, 4, 314-322. doi: 10.4236/ajac.2013.46040.