Open Journal of Applied Sciences

Volume 3, Issue 2 (June 2013)

ISSN Print: 2165-3917   ISSN Online: 2165-3925

Google-based Impact Factor: 0.92  Citations  h5-index & Ranking

ROC Analysis in Radiotherapy: A TCP Model-Based Test

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DOI: 10.4236/ojapps.2013.32025    4,209 Downloads   7,051 Views  Citations

ABSTRACT

Several mathematical models have been proposed to describe the dynamics of irradiated cancer cells and to evaluate the tumour control probability (TCP). In this article, we propose a TCP model-based statistical test for predicting the outcome of a radiation treatment. We determine the foresight capability of prostate tumour erradication (cure) from Monte Carlo simulations of the Dawson-Hillen TCP model. We construct the receiver operating characteristic (ROC) curves of the test from the probability distributions of the fraction of remaining tumour cells for simulated experiments that evolve either to cure or non-cure. Simulations show that a similar procedure may be applicable to clinical data. Results suggest that the evaluation of tumour sizes after the treatment has started may be used for short-term prognosis.

Share and Cite:

M. Santos and U. Neves, "ROC Analysis in Radiotherapy: A TCP Model-Based Test," Open Journal of Applied Sciences, Vol. 3 No. 2, 2013, pp. 186-193. doi: 10.4236/ojapps.2013.32025.

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