Open Journal of Applied Sciences
Volume 3, Issue 2 (June 2013)
ISSN Print: 2165-3917 ISSN Online: 2165-3925
Google-based Impact Factor: 0.92 Citations h5-index & Ranking
ROC Analysis in Radiotherapy: A TCP Model-Based Test ()
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ABSTRACT
Several mathematical models have been proposed to describe the dynamics of irradiated cancer cells and to evaluate the tumour control probability (TCP). In this article, we propose a TCP model-based statistical test for predicting the outcome of a radiation treatment. We determine the foresight capability of prostate tumour erradication (cure) from Monte Carlo simulations of the Dawson-Hillen TCP model. We construct the receiver operating characteristic (ROC) curves of the test from the probability distributions of the fraction of remaining tumour cells for simulated experiments that evolve either to cure or non-cure. Simulations show that a similar procedure may be applicable to clinical data. Results suggest that the evaluation of tumour sizes after the treatment has started may be used for short-term prognosis.
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