Let S be a nonempty, proper subset of all refined inertias. Then, S is called a critical set of refined inertias for ireducible sign patterns of order n if is sufficient for any sign pattern A to be refined inertially arbitrary. If no proper subset of Sis a critical set of refined inertias, then S is a minimal critical set of refined inertias for sign patterns of order n . In this paper, all minimal critical sets of refined inertias for irreducible sign patterns of order 2 are identified. As a by-product, a new approach is presented to identify all minimal critical sets of inertias for irreducible sign patterns of order 2.