Author(s)

Kayo Kuyama, Takashi Matsumoto, Miyuki Morikawa, Akira Fukatsu, Mana Ichimura, Masanobu Wakami, Masahiko Fukumoto, Taku Kato, Hirotsugu Yamamoto

Clinical Laboratory Section, Funabashi Municipal Medical Center, Chiba, Japan.
Department of Crown and Bridge Orosthodontics, Nihon University School of Dentistry at Matsudo, Chiba, Japan.
Department of Diagnostic Pathology, Hospital of Nihon University School of Dentistry at Matsudo, Chiba, Japan.
Department of Laboratory Medicine for Dentistry, Nihon University School of Dentistry at Matsudo, Chiba, Japan.
Department of Oral Pathology, Nihon University School of Dentistry at Matsudo, Chiba, Japan.

The purpose of this study was to compare among dysplasia of oral, uterine cervix and bronchus. Using a computer cytomorphometry cell measurement program, the study was based on a retrospective review of smear cases diagnosed with dysplasia of oral, bronchial and uterine cervix, from 2002 to 2010. For 50 - 70 cells from each lesion, nuclear (N) and cytoplasm (C) variables were assessed: area (A), diameter (D), irregularity (I), stain brightness and granularity. NA and ND were highest in OSCC and higher according to dysplastic grading. By contrast, CA and CD were lowest in severe dysplasia. The significant difference of N/C ratio was observed among OSCC to inflammation, mild and moderate dysplasias (p < 0.05). The N/C ratios of mild and moderate dysplasias were equal. Brightness and granularity values of OSCC cases were significantly higher than those of another (p < 0.05). About the difference between mild to moderate dysplasias, it was the easiest to detect of the uterine cervix. All severe dysplasias among the 3 regions were easily identified morphometrically. The deficient in the difference between inflammation to mild dysplasia and mild to moderate dysplasia were obtained in the oral mucosal lesion. The results displayed a significant variation in cytomorphometrical values among the 3 regions. N/C values for uterine cervix and bronchus were well distinguished in comparison with oral dysplasias. Screening of mild and moderate dysplasias requires experience which carries out the comprehensive judgment of the color.

Exfoliative Cytology; Dysplasia; Oral Mucosa; Cervix; Bronchus

Kuyama, K. , Matsumoto, T. , Morikawa, M. , Fukatsu, A. , Ichimura, M. , Wakami, M. , Fukumoto, M. , Kato, T. and Yamamoto, H. (2013) Morphometrical findings among dysplasias of oral, cervical and bronchial regions. Open Journal of Stomatology, 3, 215-222. doi: 10.4236/ojst.2013.32037.