Open Journal of Organ Transplant Surgery
Volume 3, Issue 2 (May 2013)
ISSN Print: 2163-9485 ISSN Online: 2163-9493
Google-based Impact Factor: 1 Citations
Short-Term Outcomes in Heart Transplant Recipients Treated with Generic Tacrolimus Compared to Prograf ()
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ABSTRACT
Calcineurin inhibitors are the cornerstone of solid organ transplant immunosuppression. Tacrolimus has only recently become available in a non-branded formulation, and there is little data on the efficacy and safety of generic tacrolimus, particularly following heart transplant. We performed a retrospective analysis of 21 consecutive patients who were treated with generic tacrolimus following heart transplant and compared rate of biopsy-proven acute cellular rejection to historical controls who were treated with Prograf. No significant difference in biopsy-proven acute cellular rejection was noted between the groups and rates of opportunistic infection and death were comparable. Although limited by the single-center, retrospective design, this preliminary data may be useful to clinicians facing the option of initiating generic tacrolimus following heart transplant.
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