Author(s)

Olga G. Sitnikova, Sergey B. Nazarov, Irina V. Shikhanova, Alexander V. Agafonov, Jean A. Dyuzhev, rina G. Popova

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In this study investigation of influence of hybrid nanosilica-polyethylene glycols materials (molecular weight 1500, 6000 and 15000), prepared by sol-gel synthesis, on lipid peroxidation and antioxidant activity of human serum in vitro was performed. Methods included chemiluminescence analysis and quantitative malonic dialdehyde estimation. It was revealed that nanosilica-PEG materials with different molecular weight had certain biological activity. Powders of SiO2-PEG 1500 and SiO2-PEG 6000 manifest prooxidant effects, whereas mesoporous (calcine) powders produced antioxidant effects in blood serum in vitro.

Free-Radical Oxidation, Nanosilica, Chemiluminescence, Malonic Dialdehyde

O. Sitnikova, S. Nazarov, I. Shikhanova, A. Agafonov, J. Dyuzhev and r. Popova, "The Study of Influence of Silica and Polyethilene Glycols Organic-Inorganic Compounds on Free-Radical Processes in Vitro," Pharmacology & Pharmacy, Vol. 1 No. 2, 2010, pp. 69-74. doi: 10.4236/pp.2010.12010.