Immunadsorption therapy for end stage heart failure due to Duchenne muscular dystrophy - Open Journal of Pediatrics

OJPed > Vol.3 No.1, March 2013

Open Journal of Pediatrics

Volume 3, Issue 1 (March 2013)

ISSN Print: 2160-8741 ISSN Online: 2160-8776

Google-based Impact Factor: 0.45 Citations

Immunadsorption therapy for end stage heart failure due to Duchenne muscular dystrophy ()

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Download as PDF (Size: 72KB) PP. 17-19

DOI: 10.4236/ojped.2013.31003 4,567 Downloads 7,239 Views Citations

Author(s)

Reiner Buchhorn, Christian Willaschek, Jochen Selbach, Roland Jahns

Affiliation(s)

Department of Internal Medicine I, Cardiology, Universitaet Wuerzburg, Wuerzburg, Germany.
Department of Internal Medicine III, Nephrology, Caritas Krankenhaus, Bad Mergentheim, Germany.
Department of Pediatrics, Caritas Krankenhaus, Bad Mergentheim, Germany.

ABSTRACT

We report about a successful immunadsorption therapy of a boy with end stage heart failure due to Duchenne muscular dystrophy who has little chance to get cardiac transplantation. Prior to this therapy a medical therapy with an angiotensin converting enzyme inhibitor, a low dose betablocker, an aldosterone antagonist, and diuretics failed. In consent with the patient and his parents immunoadsorption therapy employing a protein A column was performed. Due to clinical improvement the betablocker carvedilol could be titrated from 6.25 mg up to 30 mg. In the following 4 month he improves from NYHA class IV to NYHA class II and NT-Pro-BNP levels fell from 5180 pg/ml to 402 pg/ml. The mean heart rate in Holter ECG decreases from 102/min to 68/min and ejection fraction improved from 25% to 30%. The boy began to walk without any support and was able to visit school. This clinical improvement now holds on for 2 years.

KEYWORDS

Duchenne Muscular Dystrophy, Immunoadsorption Therapy, Heart Failure, Betablocker, Cardiomyopathy

Share and Cite:

Buchhorn, R. , Willaschek, C. , Selbach, J. and Jahns, R. (2013) Immunadsorption therapy for end stage heart failure due to Duchenne muscular dystrophy. Open Journal of Pediatrics, 3, 17-19. doi: 10.4236/ojped.2013.31003.

Cited by

[1]	Mass spectrometry‐based protein analysis to unravel the tissue pathophysiology in Duchenne muscular dystrophy
	PROTEOMICS–Clinical Applications, 2018

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