The role of eosinophils in asthma - Health

Health > Vol.5 No.2, February 2013

Health

Volume 5, Issue 2 (February 2013)

ISSN Print: 1949-4998 ISSN Online: 1949-5005

Google-based Impact Factor: 0.74 Citations

The role of eosinophils in asthma ()

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Download as PDF (Size: 101KB) PP. 339-343

DOI: 10.4236/health.2013.52A045 5,693 Downloads 9,132 Views Citations

Author(s)

Faris Q. Alenzi, Fahad G. B. Alanazi, Abdulaziz D. Al-Faim, Mohamed W. Al-Rabea, Waleed Tamimi, Bassel Tarakji, Omar Kujan, Ali Al-Jabri, Richard K. H. Wyse

Affiliation(s)

College of Applied Medical Sciences, Salman bin Abdulaziz University, Al-Kharj, Saudi Arabia.
College of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
Department of Microbiol & Immunology, College of Medicine, Sultan Qaboos University, Muscat, Oman.
Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Riyadh, Saudi Arabia.
Department of Pathology, Al-Farabi Medical College, Riyadh, Saudi Arabia.
Department of Pharmacy, Ministry of Health, Riyadh, Saudi Arabia.
Department of Preventive Medicine, Ministry of Health, Riyadh, Saudi Arabia.
Imperial College of Medicine, London, UK.

ABSTRACT

Asthma is a chronic inflammatory disorder of the airways characterized by recurring episodes of reversible airway obstruction, hyper-responsiveness, wheezing, breathlessness and coughing. Clinical diagnosis of asthma is based on the pattern of clinical symptoms and pulmonary fuction tests. Asthma affectes 5% - 10% of the population and the number of worldwide cases is approximately 300 milliones. The incidence of this disease is increasing particulry in western countries [1]. It is the cause of a huge economic burden to national healthcare services. In a minority of cases, asthma is potentially fatal. After a period when fatalities appeared to be increasing [2], in recent years asthma-related mortality has progressively declined due to the develop- ment of specific asthma disease management programs, as well as the extensive use of in- haled corticosteroids [3]. Inflammation of the airways is a central component in asthma. In- flammation is associated with infliltration of the airway wall with eosinophiles and or neutron- philes mast cell degranulation and T cell active- tion. Other pathological features include, sub- basement membrane thickening, loss of epithet- lial cell integrity, goblet cells hyperplasia In- crease in airway smooth muscle mass. Eosino- phils are thought to be vital in the development of airway hyperreactivity, with the eosinophil cationic protein playing a crucial role [4]. The fact that treatment of asthma with corticos-teroids reduces eosinophils numbers and decreases airway reactivity further supports this hypothesis.

KEYWORDS

Eosinophils; Asthma

Share and Cite:

Alenzi, F. , Alanazi, F. , Al-Faim, A. , Al-Rabea, M. , Tamimi, W. , Tarakji, B. , Kujan, O. , Al-Jabri, A. and Wyse, R. (2013) The role of eosinophils in asthma. Health, 5, 339-343. doi: 10.4236/health.2013.52A045.

Cited by

[1]	EOZINOFILLER VE ALERJIK HASTALIKLAR
	2020

[2]	补脾益气方对哮喘模型大鼠气道炎症反应及气道嗜酸性粒细胞浸润的影响
	2017

[3]	ASTHMA MEETING: COMPREHENSSIVE APPROACH OF ASTHMA
	2016

[4]	РАННЯЯ ДИАГНОСТИКА И ПРОГНОЗИРОВАНИЕ БРОНХИАЛЬНОЙ АСТМЫ У ДЕТЕЙ С ПЕРСИСТИРУЮЩИМ АЛЛЕРГИЧЕСКИМ РИНИТОМ
	2015

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