Open Journal of Obstetrics and Gynecology

Volume 2, Issue 3 (September 2012)

ISSN Print: 2160-8792   ISSN Online: 2160-8806

Google-based Impact Factor: 0.45  Citations  h5-index & Ranking

Possible link between congenital uterine malformations and epitheliod trophoblastic tumor

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DOI: 10.4236/ojog.2012.23046    3,606 Downloads   5,525 Views  


Background: Epitheloid trophoblast tumor (ETT) is a tenuous type of gestational trophoblastic disease. Although clinically ETT behave in variable fashion, it is considered as a potentially malignant tumor, fatal malignancy occurs in 10% of the cases. Case and Conclusion: A 41 years old patient, who previously underwent Tompkins operation because of congenital uterine septum was admitted to our clinic due to irregular bleeding. Despite of serum hCG levels under the upper limit of normal, histopathology analysis of D&C obtained endometrial samples confirmed the presence of ETT by immunostainings. Henceforth we performed prompt abdominal hysterectomy and preserved the normal structured ovaries. According to the müllerianosis theory of endometriosis aberrant differentiation or migration could cause spreading of cells throughout the fetal organogenesis of the uterus. These cells in an apoptosis week environment might correlate with the initiation of ETT. As a conclusion we suggest further studies to assess the link between ectopic cells and ETT, to gain a better understanding in the pathomechanism of the tumor.

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Farkas, B. , Kovacs, K. , Vizer, M. , Bodis, J. and Gocze, P. (2012) Possible link between congenital uterine malformations and epitheliod trophoblastic tumor. Open Journal of Obstetrics and Gynecology, 2, 227-229. doi: 10.4236/ojog.2012.23046.

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