Author(s)

Murthy Akula¹, Derek Cressy¹, Lee Collier², George Kabalka¹, Dustin Osborne¹

¹Department of Radiology, The University of Tennessee Medical Center, Knoxville, USA.
²Advion Biosciences, Ithaca, USA.

The synthesis of a promising brain imaging agent 4-[F-18]fluoro-4-deoxy-N-acetyl-1,3,6-tri-O-acetylglucosamine, 2, was successfully accomplished from commercially available N-acetyl glucosamine in 5 steps. The non-decay corrected radiochemical yield and purity were found to be 31% ± 4% (n = 3) and >98% respectively. The total reaction time for radio labelling step was 50 min.

N-Acetylglucosamine, Amyloidogenesis, Lipase-Candida rugosa

Akula, M. , Cressy, D. , Collier, L. , Kabalka, G. and Osborne, D. (2024) Synthesis of 4-[F-18]Fluoro-4-Deoxy-N-Acetyl-1,3,6-Tri-O-Acetylglucosamine, a Potential Brain Imaging PET Agent. Natural Science, 16, 19-23. doi: 10.4236/ns.2024.163003.