Author(s)

Papa Mady Sy^1*, Sidy Mouhamed Dieng², Alphonse Rodrigue Djiboune¹, Louis Augustin Diaga Diouf¹, Boucar Ndong³, Gora Mbaye¹, Mounibé Diarra¹

¹Laboratory of Physics and Pharmaceutical Biophysics, Faculty of Medicine, Pharmacy and Odontology, UCAD, Dakar, Senegal.
²Laboratory of Galenic Pharmacy, Faculty of Medicine, Pharmacy and Odontology, UCAD, Dakar, Senegal.
³Laboratory of Medical Biophysics and Nuclear Medicine, Faculty of Medicine, Pharmacy and Odontology, UCAD, Dakar, Senegal.

The objectives of this study are to understand the mechanisms involved in the stabilization of water/oil interfaces by polymeric nanoparticles (NPs) (Eudragit®). Eudragit L100 NPs of various sizes and Zeta potentials were studied and compared at a water/cyclohexane model interface using a droplet tensiometer (Tracker Teclis, Longessaigne, France). The progressive interfacial adsorption of the NPs in the aqueous phase was monitored by tensiometry. The model interface was maintained and observed in a drop tensiometer, analyzed via axisymmetric drop shape analysis (ADSA), to determine the interfacial properties. Given the direct relationship between the stability of Pickering emulsions (emulsions stabilized by solid nanoparticles) and the interfacial properties of these layers, different nanoparticle systems were compared. Specifically, Eudragit NPs of different sizes were examined. Moreover, the reduction of the Zeta potential with PEG-6000 induces partial aggregation of the NPs (referred to as NP flocs), significantly impacting the stability of the interfacial layer. Dynamic surface tension measurements indicate a significant decrease in interfacial tension with Eudragit® nanoparticles (NPs). This reduction correlates with the size of the NPs, highlighting that this parameter does not operate in isolation. Other factors, such as the contact angle and wettability of the nanoparticles, also play a critical role. Notably, larger NPs further diminished the interfacial tension. This study enhances our understanding of the stability of Pickering emulsions stabilized by Eudragit® L100 polymeric nanoparticles.

Nanoparticles, Eudragit®, PEG, Interfacial Tension, Pickering Emulsion

Sy, P. , Dieng, S. , Djiboune, A. , Diouf, L. , Ndong, B. , Mbaye, G. and Diarra, M. (2024) Eudragit^®-PEG Nanoparticles: Physicochemical Characterization and Interfacial Tension Measurements. Open Journal of Biophysics, 14, 121-131. doi: 10.4236/ojbiphy.2024.142007.