Author(s)

Yassir Aitbenkaddour¹, Meriem Nafidi¹, Harou Karam¹, Abderraouf Soummani¹, Belbachir Anas², Oumnia Benlaassel³, Benchemkha Yassine³, Benkhalifa Moncef⁴

¹Obstetrics and Gynecology Department, Faculty of Medicine and Pharmacy, Mohammed VI University Hospital Center, Marrakech, Morocco.
²Regenerative Medicine Department, Faculty of Medicine and Pharmacy, Mohammed VI University Hospital Center, Marrakech, Morocco.
³Plastic Surgery, Mohammed VI University Hospital Center, Faculty of Medicine and Pharmacy, Marrakech, Morocco.
⁴IVF & Reproductive Genetics, Picardie Jules Vernes University, Amiens, France.

Cell therapy is a promising strategy for the treatment of endometrial hypotrophy, but the origin of these cells and injection site influence the therapeutic effect of cell therapy. This preliminary study aimed to investigate the efficacy of autologous adipose mesenchymal stem cells (ASCs) transplantation in regenerating endometrium in patients with endometrial hypotrophy. This cell therapy may become a promising treatment for infertile women with endometrial hypotrophy. A descriptive prospective study including 05 patients with endometrial hypotrophy was carried out at Mohammed VI University Hospital Center in Marrakesh over a period of two years (September 2020- September 2022). The patients between 18 and 45 with an infertility with endometrial hypotrophy < 7 mm, due to intra uterine adhesions (IUA), were included in this study. Autologous ADMSCs were isolated from patient’s adipose tissue obtained by liposuction and then transplanted into uterus by transcervical instillation using an embryo transfer catheter followed by estrogen hormone therapy.

Endometrial Hypotrophy, Intra Uterine Adhesion (IUA), Stem Cells, Adipose-Derived Mesenchymal Stem Cell, Endometrial Regeneration, Infertility

Aitbenkaddour, Y. , Nafidi, M. , Karam, H. , Soummani, A. , Anas, B. , Benlaassel, O. , Yassine, B. and Moncef, B. (2023) Regenerative Effects of Adipose-Derived Mesenchymal Stem Cells on Endometrial Hypotrophy: Preliminary Study. Open Access Library Journal, 10, 1-14. doi: 10.4236/oalib.1110494.