Author(s)

Martin Kasankidi Badibanga¹, Muana Bebele Kamba^1*, Rahman Tozin¹, Charles Kia Kayembe Kitenge¹, Crispin Katombe Kakwaka², Pascal Mamenepi Atuba²

¹Départements of Gynecology and Obstetrics, University of Kinshasa, Kinshasa, Democratic Republic of Congo.
²Higher Institute of Medical Techniques of Kinshasa, Kinshasa, Democratic Republic of Congo.

Purpose: The aim was to evaluate the serum levels of D-Dimer during normal pregnancy and in that complicated by preeclampsia, identify their associations with maternal variables and gestational, and these verite role of D-Dimer in preeclampsia inflammation. Material and Methods: Cross-sectional, multicenter study conducted in Kinshasa on pregnant women carrying a single pregnancy between 24 and 40 weeks, without any co morbidities; preeclampsia pregnant women between 24 and 40 weeks, with no other co morbidity. The clinical information was collected. Serum levels of D-Dimers were measured by enzyme-linked immunosorbent assay (ELISA) in 35 Preeclampsia patients and 84 controls. Results: A total of 119 pregnant women including 84 no-preeclampsia and 35 preeclampsia were registered. Between pregnant preeclampsia and pregnant no preeclampsia, the gestational age and the BMI were significantly different (p-value < 0.001***; 0.003**). The mean D-Dimers levels were significantly higher in Preeclampsia (2723 μg/ml) (p-value < 0.001) than those in normal pregnancy (639 μg/ml). Either serum D-Dimers was independently associated with the risk Preeclampsia (p < 0.001). Conclusion: D-Dimers could be potential biomarkers to identify the severity of preeclampsia, thus mean levels of D-Dimers are the best indicator for the diagnosis of inflammation in pregnancy.

D-Dimers, Pregnancy, Preeclampsia, Intravascular Coagulation Disseminate

Badibanga, M.K., Kamba, M.B., Tozin, R., Kitenge, C.K.K., Kakwaka, C.K. and Atuba, P.M. (2023) D-Dimer Concentrations in Preeclampsia and Normal Pregnancy in Kinshasa. Open Access Library Journal, 10, 1-13. doi: 10.4236/oalib.1110630.