Author(s)

Jose Lucas Daza¹, Yaroslad de la Cruz¹, Gerardo Gutierrez¹, Luis Puello¹, Victor Aldana², Antonio Vasquez³, Orlando Ariza⁴, Alexander Ariza⁵, Andres Cardenas⁶

¹Department of Internal Medicine, Nephrology, University of Buenos Aires, Buenos Aires, Argentina.
²Department of Internal Medicine, Cardiology and Epidemiology, School of Medicine, Universidad de Los Andes, Bogotá, Colombia.
³Department of Internal Medicine, University of Buenos Aires, Buenos Aires, Argentina.
⁴Department of Internal Medicine, Cardiology, University of Buenos Aires, Buenos Aires, Argentina.
⁵Department of Internal Medicine, Hematology, University of Buenos Aires, Buenos Aires, Argentina.
⁶Department of General Medicine, University Cooperativa, Santa Marta,Colombia.

Introduction: Metabolic acidosis (MA) is a frequent alteration in chronic kidney disease (CKD) that is associated with numerous complications, which is why its correction is recommended. Oral sodium bicarbonate is currently the treatment of choice. Objective: The objective is to determine if venous bicarbonate is equal to arterial bicarbonate in the follow-up of a patient with chronic kidney disease. Materials Methods: Single-center Cross-sectional studies in a cohort of adult patients with stage 4 - 5 CKD. Samples were taken between January 2022 and January 2023, in a Clinic in the city of Ibague/ Colombia obtained from the radial artery. The inclusion criteria were: not being treated with alkaline at the time of inclusion. Results: A total of 71 patients were included, 73.2% male (52) and 26.8% female (19), with different stages: stage 3 with 5.6% (4), stage 4 with 60.6% (43), stage 5 with 33.8% (23). 66.2% were diabetic, 88.7% had arterial hypertension, and 15.5% of the patients presented hematoma as a complication and pain associated with arterial puncture. The result of mean venous bicarbonate was 18.8 with a standard deviation of 2.3, arterial bicarbonate a mean of 19.4 with a standard deviation of 2.1 with a value of P 0.46, venous pH with a mean of 7.37 with a standard deviation of 0.48 and a mean arterial pH of 7.38 with a standard deviation of 0.48 with a P value of 0.01. Values of venous bicarbonate compared to arterial bicarbonate showed no statistically significant difference in patients with chronic kidney disease, but there were more complications such as hematoma and pain in patients in the arterial puncture cohort, because of this result venous bicarbonate corresponds to arterial bicarbonate, but has less risk of complications associated with the procedure. Conclusion: Metabolic acidosis is a frequent alteration in advanced chronic kidney disease, these results showed that the values of arterial and venous bicarbonate have no statistically significant differences, but there is a greater risk of complications with arterial blood gases, due to this, venous bicarbonate could be a useful tool for patients with chronic kidney disease.

MA (Metabolic Acidosis), CKD (Chronic Kidney Disease), GFR (Glomerular Filtration Rate)

Daza, J. , de la Cruz, Y. , Gutierrez, G. , Puello, L. , Aldana, V. , Vasquez, A. , Ariza, O. , Ariza, A. and Cardenas, A. (2023) Can Peripheral Venous Gases Replace Arterial Gases in a Patient with Chronic Kidney Disease?. Open Journal of Nephrology, 13, 150-160. doi: 10.4236/ojneph.2023.132015.