Author(s)

Leena Saeed¹, Hanna Elbashir Mohamed Ali², Zeinab Abdalgadeer Ali Abdalla³, Sarra Fadlalla Elabbas³, Marwa Eltaj Eltayeb⁴, Wafa Mukhtar Mohamed Mukhtar⁵

¹Faculty of Medicine, National Ribat University, Khartoum, Sudan.
²Faculty of Medicine, Ahfad University for Women, Omdurman, Sudan.
³Dermatology Department, Khartoum Hospital, Khartoum, Sudan.
⁴Tumor Therapy Cancer Research Center, Shendi, Sudan.
⁵Faculty of Pharmacy, National Ribat University, Khartoum, Sudan.

Vertigo is a condition when a patient feels that the objects around him are moving, and this condition can lead to falls and serious incidences. Vertigo has various etiologies including central, peripheral, psychogenic, and medication-induced vertigo. The most common cause is benign paroxysmal positional vertigo (BPPV) then Meniere’s disease and labyrinthitis should be in the differential diagnosis. Ruling out serious conditions such as stroke is important. Various treatment options are used for vestibular symptoms and vestibular rehabilitation shows a positive result. Management of vertigo is the same for a long time despite the partial effect, unwanted side effects due to some drugs, and the need for multiple medications to relieve the symptoms in some patients. More effective treatment with lesser side effects needs to be used. Recently some in vivo trials come into view that H4 antagonist such as SENS-111 is effective in treating vestibular symptoms. These medications work by blocking the action of histamine, a chemical messenger involved in the immune response. More clinical trials and research need to be done on this type of treatment and other treatment options as this will lead to positive transformation in the future.

Vertigo, Dizziness, Peripheral Vertigo, Central Vertigo

Saeed, L., Ali, H.E.M., Abdalla, Z.A.A., Elabbas, S.F., Eltayeb, M.E. and Mukhtar, W.M.M. (2023) Vertigo and H4 Antagonist Effect on Vestibular Symptoms. Open Access Library Journal, 10, 1-21. doi: 10.4236/oalib.1110164.