Physicochemical Properties and Biological Activities of Novel Hydrazonate Copper Complexes ()
ABSTRACT
The objective of this research was to elucidate the
biological effect of novel compounds derived from natural product of
syringaldehyde through novel semi-synthetic method in order to investigate the physicochemical
properties and biological activities by using DPPH and FRAP techniques and its
antibacterial
activities against Klebsiella spp., Pseudomonas aeruginosa, Bacillus
cereus, and Staphylococcus aureus. Moreover, to examine its ability
against breast cancer cell line (MCF-7). The results showed that the
syringaldehyde hydrazonate copper complexes possessed the covalent bonds with
square-planar structure. In terms of antioxidant DPPH activities, it was found
that syringaldehyde hydrazone possessed high potency against DPPH free
radicals, with respect to syringaldehyde hydrazonate copper complexes. On the
other hand, all compounds possessed low reducing properties for changing Fe3+ to Fe2+ in FRAP technique. For antibacterial activities revealed that the ligand L1 and L5 possessed high effect on Pseudomonas
aeruginosa, but for all copper complexes possessed high potent
antibacterial susceptibility to four bacteria with concentration dependence. For anti-breast cancer cell line (MCF-7), it
was found that all compounds possessed high potent anticancer susceptibility with low IC50, especially, compound exhibit highly potency effective
is C5 (IC50 9.75 μM). The tendency of anticancer effect from
high to low was C5 > C2 > C1 > C4 > C3.
Therefore, all synthetic compounds obtained from the present research possibly
develop as the antibacterial drugs and the drugs for curing the diseases caused
by free radicals, including breast cancer in metastatic phase. The most
important feature of these drugs was the high specificity to the target and
harmless to the normal cells.
Share and Cite:
Patitungkho, S. and Patitungkho, K. (2023) Physicochemical Properties and Biological Activities of Novel Hydrazonate Copper Complexes.
Open Journal of Medicinal Chemistry,
13, 1-13. doi:
10.4236/ojmc.2023.131001.
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