Author(s)

Uttam Kumar Barua¹, Pranab Karmaker², Arup Kumar Saha³, Md. Merazul Mostofa⁴, Dilip Kumar Ghosh⁵, Kamal Krishna Biswas^6*

¹Department of Respiratory Medicine, Shaheed Suhrawardy Medical College Hospital, Dhaka, Bangladesh.
²Bangladesh Reference Institute for Chemical Measurements (BRiCM), Dhaka, Bangladesh.
³Department of Dental Public Health, City Dental College and Hospital, Dhaka, Bangladesh.
⁴Department of Genetic Engineering and Biotechnology, University of Rajshahi, Rajshahi, Bangladesh.
⁵Department of Gastroenterology, Shaheed Suhrawardy Medical College Hospital, Dhaka, Bangladesh.
⁶Department of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi, Bangladesh.

Bronchial asthma is a chronic inflammatory disease. Allergies are intensely related to bronchial asthma and to other respiratory diseases such as chronic sinusitis, middle ear infections, and nasal polyps. Treatment can vary from inhalers to oral medications to drugs delivered in a nebulizer or breathing machine. Besides, dietary involvement was a significant tool to reduce the severity of many chronic inflammatory diseases including asthma. Randomly assigned, double blind, and placebo controlled 290 adults with mild to moderately persistent bronchial asthma concluded in this study, were subjected to alternating phases of supplementation with omega-3 fatty acids, vitamin C and Zn either singly or in combination. Subjective symptom improvement, pulmonary function, and biochemical tests were carried out at the beginning of the study and at the end of each therapeutic phase. The study findings showed that nearly half of the cases were in age between 18 years to 40 years followed by 29.6 of the cases that fall in age range between 40 years and 60 years. It was clear that all the four supplements (ogema-3 fatty acids, vitamin C and Zn, and combination) contributed more than placebo in reducing the severity of bronchial asthma. However, omega 3 fatty acids and combined supplement significantly contributed in symptomatic improvement (p < 0.05). There was a significant improvement of pulmonary function and sputum inflammatory markers with diet supplementation (p < 0.05). So, the subjects with mild and moderately persistent bronchial asthma may get benefit from their dietary supplementation with omega 3 fatty acids, Zinc and vitamin C. It is evident from this study that omega 3 fatty acids and combined supplementation significantly improved the severity of bronchial asthma.

Bronchial Asthma, FEV1, FVC, Omega 3 Fatty Acids

Barua, U. , Karmaker, P. , Saha, A. , Mostofa, M. , Ghosh, D. and Biswas, K. (2023) The Effects of Omega-3 Fatty Acids Supplementation in Bronchial Asthma. Journal of Biosciences and Medicines, 11, 208-219. doi: 10.4236/jbm.2023.114015.