Author(s)

Berry Ikolango Bongenya^1,2, Marie-Thérèse Ayanne Safi Sombo³, Guy Makila Mabe Bumoko³, Benoit Obel Kabengele⁴, Fridolin Kule-Koto Kodondi⁵, Baudoin Bu-Tsumbu Buassa⁶, Richard Lunganza Kalala⁶, Erick Ntambwe Kamangu^2,6*

¹Faculty of Medicine, Bel Campus Technological University, Kinshasa, Democratic Republic of the Congo.
²“Focus HIV/AIDS” Research Group, Kinshasa, Democratic Republic of the Congo.
³Department of Neurology, Faculty of Medicine, University of Kinshasa, Kinshasa, Democratic Republic of the Congo.
⁴Service of Infectious Diseases, Department of Internal Medicine, University Clinic, Faculty of Medicine, University of Kinshasa, Democratic Republic of the Congo.
⁵Laboratory of Biochemistry, Faculty of Pharmaceutical Sciences, University of Kinshasa, Kinshasa, Democratic Republic of the Congo.
⁶Service of Molecular Biochemistry, Department of Basic Sciences, Faculty of Medicine, University of Kinshasa, Kinshasa, Democratic Republic of the Congo.

Context: The biochemical assessment is a real-time indicator of the state and evolution of an infection. Among other things, it makes it possible to determine the right moment when it becomes necessary to start or change a treatment. Objective: The objective of this study is to present the Biological profile of People Living with HIV starting AntiRetroViral treatment in Kinshasa in the era of Dolutegravir. Methods: The present study is a descriptive cross-sectional to determine the biological profile of People Living with HIV (PLHIV) starting AntiRetroViral Treatment (ART). The patient inclusion period was from October 4, 2021 to February 15, 2022. Sixteen centers were included. A sample of 5 ml of blood was taken in a tube with EDTA. Patients were randomly included consecutively in the centers during consultations. The population was made up of adults aged over 18, infected with HIV and starting ART. The parameters of interest retained for the present study were: sex, age, hemoglobin level, blood sugar, urea, creatinine, transaminases, total cholesterol, triglycerides, proteins total, as well as amylase. Results: 119 patients were included in this study in accordance with the inclusion criteria; 67 (56.3%) are female, giving a sex ratio of 1.29 in favor of women. The average age of the patients is 39.87 ± 12.36 years. The most represented age group is that of 36 to 45 years with 37 patients (31.9%). The mean values of the biological parameters of the patients at the start of ART are as follows: 31.61 ± 20.71 IU/L for ALT/SGPT, 25.81 ± 19.96 IU/L for AST/SGOT, 79.35 ± 49.49 IU/L for Amylase, 108.13 ± 62.17 mg/dl for Total Cholesterol, 2.77 ± 1.27 mg/dl for Creatinine, 72.53 ±22.23 mg/dl for Glycaemia, 10.30 ± 2.33 g/dl for Hemoglobin, 7.91 ± 1.75 g/dl for Total Protein, 131.23 ± 68.80 mg/dl for Triglycerides, and 33.61 ± 26.27 mg/dl for Urea. Conclusion: Mean values of PLHIV are, for the most part, within the normal range. The average creatinine is higher than the normal average value while the average total cholesterol is below the limit values.

Biological Profile, PLHIV, Starting ART, Kinshasa

Bongenya, B. , Sombo, M. , Bumoko, G. , Kabengele, B. , Kodondi, F. , Buassa, B. , Kalala, R. and Kamangu, E. (2023) Biological Profile of People Living with Human Immunodeficiency Virus Starting Treatment in Kinshasa, Democratic Republic of the Congo. World Journal of AIDS, 13, 1-10. doi: 10.4236/wja.2023.131001.