Author(s)

Zhenqi Xu, Wei Du^*

Department of Oncology, The First Affiliated Hospital of Yangtze University, Jingzhou, China.

PD-1 and its ligands PD-L1 and PD-L2 are widely expressed on the surface of a variety of cells and are a group of costimulatory molecules related to negative immune regulation. The activation of the PD-1/PD-L1 signaling pathway is beneficial for tumors to escape from immune surveillance, but the specific tumor immune escape mechanism is not yet clear. As far as the efficacy of anti-PD-1 and anti-PD-L1 antibodies is concerned, more in-depth research on tumor immune escape mechanisms is still needed. The article summarizes these findings to provide ideas for antitumor immunotherapy.

Programmed Death 1, Programmed Death Ligand 1, Neoplasms, Immunotherapy

Xu, Z. and Du, W. (2023) PD-1/PD-L1 Signaling Pathway and Tumor Immune Escape. Journal of Biosciences and Medicines, 11, 9-16. doi: 10.4236/jbm.2023.113002.