Author(s)

Kamo Irié Lou Bohila Emilie¹, Tra Bi Irie Otis^2,3, Kouassi Kouakou Serge^4*, Djaman Allico Joseph^2,4, N’guessan Jean David⁴

¹Department of Microbiology, Institut Pasteur of Côte d’Ivoire, Abidjan, Côte d’Ivoire.
²Department of Medical and Fundamental Biochemistry, Institut Pasteur of Côte d’Ivoire, Abidjan, Côte d’Ivoire.
³Superior Normal School, Abidjan, Côte d’Ivoire.
⁴Biology and Health Laboratory, Félix Houphouët-Boigny University, Abidjan, Côte d’Ivoire.
⁴Biology and Health Laboratory, Félix Houphou?t-Boigny University, Abidjan, Côte d’Ivoire.

Terminalia mantaly H. Perrier is one of the plants of the Combretaceae family that is widely used in traditional African medicine for its antibacterial, antifungal, and especially in the treatment of malaria. In this study, we evaluated the effect of the hydroalcoholic extract of Terminalia mantaly (HAETM) on the tissue and kidney biochemical markers of rats. Forty (40) rats were randomly divided into 4 groups, assigning 10 animals within each group (5 males and 5 females per group). Animals in group 1 received distilled water and were used as the control group; on the other hand, groups 2, 3, 4 received by gavage a volume of the extract corresponding to 1 ml/100g body weight at 150 mg/kg, 300 mg/kg, 600 mg/kg, respectively. The hydroalcoholic extract was administered at the same time daily for 28 days, and blood was collected once a week to evaluate renal biochemical parameters; the kidney tissues were used to perform the histopathological study. The creatinine rate increased significantly (p < 0.001). The analysis of the serum electrolytes reveals a significant decrease in the levels of sodium, potassium, and creatinine (p < 0.005). The kidney micrograph did not show any adverse effects in the different groups of animals treated with the hydroalcoholic extract. Hydroalcoholic extract of Terminalia mantaly should be globally well tolerated by the body when used in doses ranging from 150 to 600 mg/kg of the body weight in animals (for this study, rats). However, further in-depth studies would be needed to get a more thorough and complete picture of the safety profile of the extract.

Terminalia mantaly, Biotolerance, Biochemical Markers

Emilie, K. , Otis, T. , Serge, K. , Joseph, D. and David, N. (2022) Biotolerance Study of the Hydroalcoholic Extract of Terminalia mantaly H. Perrier on Rat Renal Activity. Journal of Biosciences and Medicines, 10, 167-179. doi: 10.4236/jbm.2022.1012014.