Author(s)

Siyu Zhou¹, Yu Wu¹, Yili Cai¹, Zecheng Yu², Ruirui Li², Chunwei Yan³, Fangwei Dai^3,4, Wei Han^3,4*

¹School of Clinical Medicine, Hangzhou Medical College, Hangzhou, China.
²School of Medical Imaging, Hangzhou Medical College, Hangzhou, China.
³Laboratory of Animal Center, Hangzhou Medical College, Hangzhou, China.
⁴Zhejiang Provincial Key Laboratory of Laboratory Animals and Safety Research, Hangzhou, China.

Autophagy is an important biological mechanism to transport proteins in organelles to lysosome for degradation, maintaining a stable physiological balance of the body. Acute Myeloid Leukemia (AML) refers to hematological malignancy caused by a disorder of myeloid hematopoietic stem cells. Recent studies have shown that the expression of some autophagy-related genes in AML patients is closely related to the prognosis and leukocyte formation of AML patients. Therefore, we can use autophagy as a potential target for monitoring, prognosis, and molecular diagnosis of leukemia patients. The study summarized the interaction between AML and autophagy-related signal pathways (such as mTOR and PI3K pathway) and explained the influence of related inhibitors and activators on AML cells in recent years, which laid a theoretical foundation for clinical treatment and research development of AML patients.

Autophagy, Acute Myeloid Leukemia, Signaling Pathway, Clinical Treatment

Zhou, S.Y., Wu, Y., Cai, Y.L., Yu, Z.C., Li, R.R., Yan, C.W., Dai, F.W. and Han, W. (2022) The Role of Autophagy in Acute Myeloid Leukemia. Open Access Library Journal, 9, 1-13. doi: 10.4236/oalib.1109476.