Author(s)

Marie Louise Bassène^1*, Salamata Diallo¹, Marieme Polele Fall¹, Mame Aissé Thioubou², Téné Sidibé¹, Coumba Cissé¹, Mamadou Ngoné Gueye³

¹Department of Gastroenterology and Hepatology, Hospital Aristide Le Dantec, Dakar, Senegal.
²Department of Gastroenterology and Hepatology, Peace Hospital, Ziguinchor, Senegal.
³Department of Gastroenterology and Hepatology, Hospital Idrissa Pouye, Dakar, Senegal.

Introduction: Liver cirrhosis is a global public health issue. Our aim was to determine the epidemiological, clinical, paraclinical and therapeutic aspects of liver cirrhosis in the hepato-gastroenterology department of the hospital Aristide Le Dantec in Dakar. Patients and Methods: We conducted a retrospective study with a descriptive focus covering the period from January 1st, 2010 to December 31, 2020. We included the medical records of patients which presented body of clinical and paraclinical arguments which supported the diagnosis of cirrhosis. The data collected were related to age, gender, clinical, paraclinical, therapeutic and prognosis aspects of cirrhosis and were analyzed with the software Sphinx Plus. Results: Prevalence of cirrhosis was 6.2%. Sex ratio was 2.1%. The average age was 38 years. Asthenia (60.9%), altered performance status (60.1%), abdominal pain (37.2%), gastrointestinal bleeding (29.6%) and abdominal swelling (27.8%) were the most common motives of consultation. Physical examination revealed primarily portal hypertension (74.9%), liver failure (2.4%), hepatomegaly (28.2%) and anemia (13.7%). Viral hepatitis B was the most common etiology (81.9%). Abdominal screening (ultrasound/CT scan) showed hepatomegaly (80.6%), liver dysmorphia (87.7%), portal hypertension signs (85.3%) and portal vein thrombosis (18.2%). 55.1% Patients were classified as Child Pugh A, 33.8% were Child Pugh B and 11.1% were Child Pugh C. Tenofovir Disoproxil Fumarate (TDF) was prescribed to all patients affected by hepatitis B virus only. Evolution was characterized by clinical improvement and prognosis reclassification. Conclusion: Liver cirrhosis is a frequent pathology in the hepato-gastroenterology department of the hospital Aristide Le Dantec in Dakar. It affects young male adult. Hepatitis B virus is the leading cause. TDF is an effective treatment.

Cirrhosis, Viral Hepatitis B, Portal Hypertension, Liver Failure, Hepatomegaly

Bassène, M. , Diallo, S. , Fall, M. , Thioubou, M. , Sidibé, T. , Cissé, C. and Gueye, M. (2022) Epidemiological, Clinical, Paraclinical, Etiological and Therapeutic Aspects of Liver Cirrhosis in the Hepato-Gastroenterology Department of the Hospital Aristide Le Dantec in Dakar. Open Journal of Gastroenterology, 12, 317-323. doi: 10.4236/ojgas.2022.1211032.