Author(s)

Omédine Koukoui^1*, Santorin Seton¹, Mansouratou Betira¹, Jean Baptiste Amagbegnon¹, Fidèle Sonounameto¹, Eudoxie Assou², Alphonse Sezan²

¹Laboratory of Animal Physiology, Cellular Signaling and Pharmacology, ENSBBA/UNSTIM, Dassa Zoumè, Benin.
²Laboratory of Pharmacology and Improved Traditional Medicines, FAST/University of Abomey-Calavi, Godomey, Benin.

Cardiovascular diseases (CVD) are nowadays real health problems in the world. High blood pressure is one of the most important risk factors for CVD and is affecting more and more people in Benin. The objective of our work is to evaluate the safety and the efficacy of the leaves of five plants used for the treatment of hypertension in Benin. Acute toxicity was evaluated on wistar rats which orally administered a single dose of 2000 mg/kg of body weight of hydro-ethanolic extract of the leaves of Phyllanthus amarus Schumach. & Thonn., Persea americana MILL., Ipomoaea fistulosa Mart. ex Choisy., Heliotropium indicum L., Schrankia leptocarpa DC., and were monitored over a period of 14 days. Subacute toxicity was evaluated on rats which received a daily dose of 200 mg/kg of body weight of the plant leaf extract over a period of 28 days. Plant efficacy was assessed by measuring potassium in plant leaves. Administration of the single dose of the extract did not cause any deaths in rats; the weight of the rats varied depending on the extracts administered. Concerning the subacute treatment, the levels of aspartate amino transaminases (AST) and Alanine amino transaminases (AST) did not vary significantly after the 28 days of treatment with the different extracts. On the other hand, a significant increase in serum creatinine was observed in rats treated with extracts of Phyllanthus amarus. The leaves of Heliotropium indicum, Ipomoaea fistulosa and Phyllanthus amarus contain the highest levels of potassium. Among the five plants studied, only the leaves of Phyllanthus amarus seem to induce renal toxicity. Extracts from the leaves of Heliotropium indicum, Ipomoaea fistulosa might be the most effective in inducing hypotensive activity and do not show toxicity.

Hypertension, Plant Extracts, Toxicity, Efficacy, Potassium

Koukoui, O. , Seton, S. , Betira, M. , Amagbegnon, J. , Sonounameto, F. , Assou, E. and Sezan, A. (2022) Evaluation of the Safety and Efficacy of Extracts from the Leaves of Five Plants Used for the Treatment of Arterial Hypertension in Benin. Pharmacology & Pharmacy, 13, 355-367. doi: 10.4236/pp.2022.1310027.