Author(s)

Shailesh Simkhada¹, Shravana Aryal², Albert D. Osei³, Ashik Pokharel³, Rami Matar⁴, Michael Maitar²

¹Springfield Memorial Hospital, Springfield, Illinois, USA.
²Southern Illinois University, Springfield, Illinois, USA.
³Medstar Health Internal Medicine, Baltimore, Maryland, USA.
⁴St. George’s University, West Indies, Grenada.

Background and Aims: Periampullary malignancies often present at an advanced unresectable stage requiring palliation of symptoms for the better quality of life. Though they require multispecialty support; role of endoscopic interventions in palliation is paramount because of the advancement in technology and increase experience of Gastroenterologist. Methods: We did extensive review of articles regarding endoscopic advances in the management of Unresectable Periampullary Malignancies. Several systematic reviews, Meta analysis, and Randomized controlled trials published over the last 2 decades were thoroughly searched on PUBMED and GOOGLE SCHOLAR. Results: Advanced Endoscopic procedures have been emerging as a superior modality than conventional measures because of minimal invasiveness and greater clinical and technical success. Conclusion: Periampullary malignancies often present at an advanced unresectable stage requiring palliation of symptoms for the better quality of life. Several endoscopic interventions have already been established as the standard of care in palliation of symptoms of unresectable periampullary malignancies, we can say with confidence that with growing advances in EUS, advancement in technologies and increasing experiences, the role of gastroenterologist will be pivotal in these groups of patients.

Periampullary Malignancies, Endoscopic Ultrasound, Celiac Plexus Neurolysis, ERCP, EUS-BD, EUS-GE

Simkhada, S. , Aryal, S. , Osei, A. , Pokharel, A. , Matar, R. and Maitar, M. (2022) Advanced Endoscopic Palliation of Unresectable Periampullary Carcinoma: A Systematic Review. Open Journal of Gastroenterology, 12, 249-262. doi: 10.4236/ojgas.2022.1210025.