Author(s)

Haiyan Lin¹, Chenyun Xu^2*

¹The Fourth People’s Hospital of Haikou, Haikou, China.
²Hainan General Hospital, Haikou, China.

Objective: To investigate the correlation between recurrent spontaneous abortion patients and brain derived neurotrophic factor BDNF gene polymorphism and the mechanism of BDNF and recurrent spontaneous abortion under stress state in order to provide theoretical basis for nursing psychological intervention of patients with recurrent abortion. Methods: Medical coping Questionnaire (MCMO) and post-traumatic stress Diagnostic Scale (POST-traumatic stress Scale) were adopted Dissorder (PTSD) (PCL-c) scale was used to diagnose the psychological stress of recurrent spontaneous abortion in our hospital, and the BDNF gene polymorphism and the correlation factors of METHYLation in BDNF promoter region were studied in 30 cases (control group) and normal control group. Results: The MCMQ score of the case group and the control group was significantly lower than that of the conventional group (P < 0.05), and the scores of “avoidance and submission” were higher than that of the conventional group, with statistical significance (P < 0.05). The distribution of BDNF gene g-712A genotype was significantly different between the case group and the control group. Conclusion: There are significant differences in PTSD between the case group and the control group, which are related to methylation in the PROMOTER region of BDNF and SNP g-712A of BDNF gene. AG patients in the case group are more susceptible to anxiety and depression, and GG PTSD is more severe in the case group. BDNF promoter methylation and G-712A were independent risk factors for PTSD in the case group.

Recurrent Spontaneous Abortion, BDNF, Psychological, Care to Do

Lin, H. and Xu, C. (2022) Correlation of BDNF Gene Polymorphism and Psychological Nursing Intervention in Patients with Recurrent Spontaneous Abortion. Health, 14, 910-920. doi: 10.4236/health.2022.148064.