Elucidation of the Probable Ovarian-Dependent Mechanism of the Estrogenic Effects of Buccholzia coriacea and Progesterone Effects of Cogniauxia pololeana in the Rat ()
ABSTRACT
The present study was carried out with the
objective of evaluating, in castrated rats, the utero trophic, hormonal and
biochemical activities of aqueous extracts of Buchholzia coriacea (BC)
and Cogniauxia podolaena (CP) leaves. Each extract administered at the
dose of 600 mg/Kg in castrated rats did not cause a significant change in the
fresh weight/dry weight ratio of the uterus compared to castrated rats given
distilled water. However, those receiving 17-β-estradiol as a reference product showed a
significant (p < 0.5) increase in this ratio. These results indicate the
absence of uterotrophic effects of both extracts in the ovariectomized rat
compared with the effects of 17-β estradiol. In addition,
the extracts did not cause significant changes in estrogen or progesterone
levels in treated rats, as observed with 17-β-estradiol. In addition, the determination of
protein and total cholesterol in the uterus of castrated rats treated with each
extract did not show significant variation from controls. At the time, castrated rats treated with 17-β-estradiol showed a significant increase (p <
0.5) in uterine protein level and a significant decrease (p < 0.5) in total
cholesterol level. Only the blood protein level was significantly increased in
the castrated rats that received the extracts. These results suggest that the
respective estrogenic and progesterone effects of the extracts of the two
plants may be ovarian-dependent, these plants would not contain phytohormones.
Share and Cite:
Peneme, B. , Ossibi, A. , Akassa, H. , Ondélé, R. and Abena, A. (2022) Elucidation of the Probable Ovarian-Dependent Mechanism of the Estrogenic Effects of
Buccholzia coriacea and Progesterone Effects of
Cogniauxia pololeana in the Rat.
Open Journal of Applied Sciences,
12, 1284-1295. doi:
10.4236/ojapps.2022.127088.
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