Author(s)

Camila dos Santos Leite^1,2, Naira Correia Cusma Pelógia³, Eliane Stevanato³, Marília Hidalgo Uchôas³, Gabriela Apóstulo Silva³, Guilherme Apóstulo Silva³, Carlos Augusto Pires Zerbini³, Marta Helena Rovani Pires⁴, Oscar César Pires³

¹Laboratory of Immunopharmacology and Molecular Biology, São Francisco University Medical School, Bragança Paulista, Brazil.
²Laboratory of Cell and Molecular Tumor Biology and Bioactive Compounds, São Francisco University Medical School, Bragança Paulista, Brazi.
³Laboratory of Pharmacology and Physiology, Medicine Department, Taubaté University, Taubaté, Brazil.
⁴Vera Cruz Hospital, Campinas, Brazil.

Opioid-induced hyperalgesia negatively affects physiological pain management and presents a complex causal mechanism, involving, pharmacodynamic and pharmacokinetic factors of interactions with receptors, opioid-independent ascending systems and with pro-nociceptive systems. After approval by the CEUA, 42 male Wistar rats were divided into 7 groups: In group 1 (GCSSL) the animals received 1 ml of 0.9% saline solution intraperitoneally (IP); in group 2 (GFTSL), they received fentanyl at a dose of 100 ug·kg^-1 IP; in the remaining groups (3, 4, 5, 6 and 7) the animals received IP, fentanyl at a dose of 100 ug·kg^-1 followed also by IP route of: group 3 (GFTKP) ketoprofen at a dose of 5 mg·kg^-1; group 4 GFTKT), ketamine up to a dose of 10.0 mg·kg^-1; group 5 (GFTLI), incisional lidocaine up to a dose of 10 mg·kg^-1; group 6 (GFTLP), intraperitoneal lidocaine up to a dose of 10 mg·kg^-1 and group 7 (GFTPP), propofol up to a dose of 60 mg·kg^-1. Under general anesthesia, all animals with a plantar surgical incision. Hyperalgesia was evaluated by applying Von Frey filaments on the 2nd, 1st, 3rd and 5th days after treatment. In the 2nd hour and on the 5th day after the procedure, there was no hyperalgesia associated with the use of fentanyl, however, on the 1st and 3rd postoperative days there was hyperalgesia that was attenuated by ketoprofen, ketamine, lidocaine infiltrated in the incision and intraperitoneally, an effect not observed with the use of propofol. The results suggest fentanyl-induced hyperalgesia and the efficacy of ketoprofen, ketamine, incisional lidocaine and intraperitoneal lidocaine in reducing this effect.

Hyperalgesia, Fentanyl, Ketoprofen, Ketamine, Lidocaine, Propofol, Rats

dos Santos Leite, C. , Pelógia, N. , Stevanato, E. , Uchôas, M. , Silva, G. , Silva, G. , Zerbini, C. , Pires, M. and Pires, O. (2022) Effects of Ketoprofen, Ketamine, Lidocaine and Propofol on Fentanyl-Induced Hyperalgesia in Rats. Journal of Biosciences and Medicines, 10, 53-63. doi: 10.4236/jbm.2022.107004.