Biermer Disease in an Unusual Neurological Presentation without Anemia: A Case Report - Open Journal of Gastroenterology

OJGas > Vol.12 No.5, May 2022

Open Journal of Gastroenterology

Volume 12, Issue 5 (May 2022)

ISSN Print: 2163-9450 ISSN Online: 2163-9469

Google-based Impact Factor: 0.23 Citations

Biermer Disease in an Unusual Neurological Presentation without Anemia: A Case Report ()

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Download as PDF (Size: 287KB) PP. 129-135

DOI: 10.4236/ojgas.2022.125013 80 Downloads 603 Views

Author(s)

Nsenga Djapa Guy Roger^1,2*, Fogang Fogoum Yannick¹, Ndjitoyap Ndam Antonin Wilson³, Kowo Pierre Mathurin³, Ankouane Andoulo Firmin³, Choukem Simon Pierre¹

Affiliation(s)

¹Department of Internal Medicine and Specialties, Faculty of Medicine and Pharmaceutical Sciences, University of Dschang, Dschang, Cameroon.
²Gastroenterology Unit, Internal Medicine Service, Ebolowa Regional Hospital, Ebolowa, Cameroon.
³Department of Internal Medicine and Specialties, Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Ya-oundé, Cameroon.

ABSTRACT

Background: Biermer disease is a megaloblastic disease caused by vitamin B12 deficiency. It is a rare clinical entity especially in subsahara Africa. Case presentation: We report the case of a 45 years old female patient who consulted for a one month history of generalised muscle cramps, weakness and numbness of all four limbs. Physical examination was relevant for a poor gait, poor coordination of both upper and lower limbs, a positive Romberg sign, normal muscle tone in all four limbs, reduced pallesthesia and deep tendon reflexes, abolished plantar reflexes. Paraclinical investigations revealed macrocytosis without anemia, a low cyanocobalamin (vitamin B₁₂) level with a normal folic acid level, an atrophic corporeofundic mucosa which upon pathological analysis revealed a chronic atrophic gastritis with no Helicobacter pylori infection. Anti-intrinsic factor antibodies were positive while anti parietal cells antibodies were negative. The diagnosis of Biermer disease was considered and the patient did well on vitamin B₁₂ supplementation. Conclusion: Though a rare disease, Biermer disease should be considered in a patient who consults for polyneuropathy even in the absence of anemia.

KEYWORDS

Biermer Disease, Pernicious Anemia, Autoimmune Disease, Atrophic Gastritis, Vitamin B12 Deficiency, Cameroon

Share and Cite:

Roger, N. , Yannick, F. , Wilson, N. , Mathurin, K. , Firmin, A. and Pierre, C. (2022) Biermer Disease in an Unusual Neurological Presentation without Anemia: A Case Report. Open Journal of Gastroenterology, 12, 129-135. doi: 10.4236/ojgas.2022.125013.

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