Author(s)

Mo’men Salem^1*, Rezk Ayyad², Helmy Sakr², Ahmed Gaafer³

¹Medicinal Chemistry Department, Faculty of Pharmacy, Sinai University, Northern Sinai, Egypt.
²Pharmaceutical Chemistry Department, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt.
³Medical Services Sector, Ministry of Intrior, Cairo, Egypt.

In this work we synthesized new derivatives from Phenyl Hydrazine and series of different Aldehydes (derivatives of benzylidenes). The synthesized compounds contain different aromatic Aldehydes which attached by Benzene ring via Hydrazine moiety in glacial acetic acid. These derivatives were characterized by TLC, melting points, Infrared Red, Proton Nuclear Magnetic Resonance, Carbon Thirteen Nuclear Magnetic Resonance and Mass Spectroscopy. Finally, these synthesized derivatives were tested for antiproliferative activity against multiple normal and cancerous cell lines, HepG2 (Liver cancer) and MCF-7 (Breast cancer) cell lines were used for cytotoxic assay.

Phenyl Hydrazine, Aromatic Aldehydes, Benzylidene Synthesis, Cytotoxic Assay, Anticancer, HepG2 and MCF-7

Salem, M. , Ayyad, R. , Sakr, H. and Gaafer, A. (2022) Design and Synthesis of New Compounds Derived from Phenyl Hydrazine and Different Aldehydes as Anticancer Agents. International Journal of Organic Chemistry, 12, 28-39. doi: 10.4236/ijoc.2022.121003.