Author(s)

Ahmadou Bamba Mbodji¹, Alassane Mamadou Diop^2*, Momo Banda Ndiaye¹, Serigne Saliou Mbacke¹, Khalifa Ababacar Mbaye¹, Rokhaya Diagne¹, Ibrahima Niang³, Ndiaga Matar Gaye¹, Maouly Fall², Adjaratou Sow¹, Anna Basse¹, Lala Bouna Seck¹, Moustapha Ndiaye¹, Amadou Gallo Diop¹

¹Department of Ibrahima Pierre Ndiaye Neuroscience, Fann Hospital, Dakar, Sénégal.
²Department of Neurology, Pikine Hospital, Dakar, Sénégal.
³Department of Radiology, Fann Hospital, Dakar, Sénégal.

Creuzfelt-Jakob Disease is a rare and progressive neurodegenerative disease that results in fatal, transmissible, subacute, spongiform encephalopathy characterized by rapidly progressive dementia and movement disorder. We present a 62-year-old male with no medical history who was admitted to our hospital because of gait and balance disturbance, language impairment and progressive motor deficit of the four limbs. A neurological examination found frontal lobe syndrome signs, myoclonic movements, pyramidal and extra-pyramidal signs. Brain Magnetic Resonance Imaging detected high intensity areas in the basal ganglia. EEG showed generalized triphasic sharp-wave complexes. A Cerebro Spinal Fluid examination found protein 14-3-3. Death occurred six months after onset. This is the first known case of Creuzfelt-Jakob Disease documented in Senegal.

Creutzfeldt-Jakob Disease, Protein 14-3-3, Prion Disease, Rapidly Progressive Dementia

Mbodji, A. , Diop, A. , Ndiaye, M. , Mbacke, S. , Mbaye, K. , Diagne, R. , Niang, I. , Gaye, N. , Fall, M. , Sow, A. , Basse, A. , Seck, L. , Ndiaye, M. and Diop, A. (2022) Creutzfeldt Jacob’s Disease: A Senegalese Observation. Neuroscience and Medicine, 13, 43-48. doi: 10.4236/nm.2022.131003.