Author(s)

Jiming Li^1*, Meide Wei^2*, Linghong Wang¹, Yanbo Wu¹, Lu Kang¹, Yan Tang¹, Huan Zhao^3#, Yubiao Sun^4#

¹Laboratory Department of the Second Affiliated Hospital of Guilin Medical College, Guilin, China.
²Laboratory Department of the Fourth Affiliated Hospital of Guangxi Medical University, Liuzhou, China.
³Laboratory Department of Chongzuo Maternal and Child Health Hospital, Chongzuo, China.
⁴Laboratory Department of the Second People’s Hospital of Mengshan County, Mengshan County, China.

Objective: To investigate the antibacterial effect of baicalin combined with cefoperazone-sulbactam sodium on drug-resistant strains of Pseudomonas aeruginosa. Method: Pseudomonas aeruginosa strains that are sensitive and resistant to cefoperazone-sulbactam sodium were selected to prepare different test bacterial solutions respectively; The test solutions of baicalin and cefoperazone sulbactam sodium were prepared respectively, and different test groups and control groups were set up; The drug sensitivity tests of different concentration gradients of baicalin and cefoperazone sulbactam sodium used alone and in combination were carried out for different sensitive and drug-resistant strains, and the standard strains were used as parallel control. Result: The drug susceptibility test results of the combined use of baicalin and cefoperazone-sulbactam against Pseudomonas aeruginosa drug-resistant strains were compared with the drug susceptibility results of the two used separately, and the difference was statistically significant (P < 0.05); The combined effect of the two was dependent on strain and concentration. Conclusion: The combined use of baicalin and cefoperazone-sulbactam sodium has a certain synergistic bacteriostatic or bactericidal effect on drug-resistant strains of Pseudomonas aeruginosa.

Baicalin, Cefoperazone-Sulbactam Sodium, Combined Use, Pseudomonas aeruginosa, Drug Resistance, Antibacterial

Li, J. , Wei, M. , Wang, L. , Wu, Y. , Kang, L. , Tang, Y. , Zhao, H. and Sun, Y. (2022) The Study of Effect of Commercial Baicalin Combined with Cefoperazone Sulbactam Sodium on Pseudomonas aeruginosa in Vitro . Natural Science, 14, 117-124. doi: 10.4236/ns.2022.143011.